Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity
نویسندگان
چکیده
منابع مشابه
Photooxidation of RPE lipofuscin bisretinoids enhances fluorescence intensity
Light-related cycling of chemically reactive vitamin A aldehyde leads to the formation autofluorescent bis-retinoid pigments that accumulate as lipofuscin in retinal pigment epithelial cells. The amassing of these diretinoid compounds is implicated in the pathogenesis of age-related macular degeneration and in some inherited forms of retinal degeneration. For all of these fluorophores, extended...
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The autofluorescence of the retina that originates primarily from lipofuscin fluorophores in retinal pigment epithelial cells, is observed to undergo photobleaching during the acquisition of fundus autofluorescence images. Bisretinoid fluorophores isolated from retinal pigment epithelial cells have the spectral characteristics consistent with their being the source of fundus autofluorescence. C...
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ژورنال
عنوان ژورنال: Vision Research
سال: 2010
ISSN: 0042-6989
DOI: 10.1016/j.visres.2009.09.015